Formulation useful for the inhibition of massive release of cere

Details Formulation useful for the inhibition of massive release of cere Formulation useful for the inhibition of massive release of cere

1992-05-20

1993-09-07

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 31395

Patent

active

052429156

ABSTRACT:
A method useful for the treatment or prevention of diseases caused by a massive release of cerebral glutamate, in particular epilepsy and dementia, and pharmaceutical formulations therefor, which comprise, as an active ingredient, a therapeutically effective amount of methyl (+)-(4S)-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2,3-b]pyr idine-5-carboxylate (S-312-d).

REFERENCES:
patent: 4703051 (1989-10-01), Adachi et al.
Chem. Abst. 114-35719.RTM.(1991).
Scriabine et al., The FASEB Journal, vol. 3, May 1989 pp. 1799-1806.
Tollefson, Biol. Psychiatry, vol. 27, No. 10, May 15, 1990 pp. 1133-1142.
Masui et al., Drug Development Research, vol. 20, 1990 pp. 453-464.

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