Formulation solubilizing water-insoluble agents and...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

Reexamination Certificate

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Details

C424S489000

Reexamination Certificate

active

06994862

ABSTRACT:
The present invention relates to an anhydrous liquid composition wherein monoglyceride is mixed with an emulsifier and a solvent, and the manufacturing method thereof, and more specifically, to an anhydrous liquid composition wherein monoglyceride is mixed with a water-insoluble material, an emulsifier and a solvent, and the manufacturing method thereof. Further, the present invention relates to a lyophilized powder and the manufacturing method thereof, wherein the lyophilized powder is prepared by dissolving the mixed liquid composition in water, adding with a cryoprotectant followed by the lyophilization. In the process of dispersion, the lyophilized liquid composition and the powder of the present invention can spontaneously generate particles of 200-500 nm by gently shaking with hands without a powerful mechanical force. Also the lyophilized liquid composition and the powder of the present invention are physicochemically stable since they neither contain water that causes oxidation or hydrolysis upon storage nor undergo phase separation. Considering all the raw materials of the present invention are biocompatible, the present invention will be useful in medical and pharmaceutical fields such as drug delivery.

REFERENCES:
patent: 5438072 (1995-08-01), Bobee et al.
patent: 5531925 (1996-07-01), Landh et al.
patent: 5958876 (1999-09-01), Woo
patent: 6214375 (2001-04-01), Modi
patent: 6248363 (2001-06-01), Patel et al.
patent: 6531139 (2003-03-01), Gao et al.
patent: 6569478 (2003-05-01), Leser et al.
patent: WO 99/06024 (1999-02-01), None
patent: WO 99/06043 (1999-02-01), None
patent: WO 99/47004 (1999-09-01), None

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