Formulation of stabilized cationic transfection agent(s)...

Details Formulation of stabilized cationic transfection agent(s)... Formulation of stabilized cationic transfection agent(s)...

2005-04-26

2005-04-26

Ketter, James (Department: 1636)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C435S320100, C435S458000, C536S023100, C536S024500

Reexamination Certificate

active

06884430

ABSTRACT:
The invention concerns a composition containing stabilized particles of cationic transfection agents
ucleic acid complexes characterized in that it includes besides said transfection agent and nucleic acid at least a non-ionic surfactant in sufficient amount for preventing the aggregation of the particles in course of time. In a preferred embodiment, the surfactant is a polyoxyalkylene or a derivative thereof.

REFERENCES:
patent: 5789244 (1998-08-01), Heidrun et al.
patent: 6086913 (2000-07-01), Tam et al.
patent: 6534484 (2003-03-01), Wheeler et al.
patent: WO 9604932 (1996-02-01), None
patent: WO 9630051 (1996-10-01), None
patent: WO 9640964 (1996-12-01), None
patent: WO 9711682 (1997-04-01), None
Liu et al., New Cationic Lipid Formulations for Gene Transfer, Pharmaceutical Research, vol. 13(12): 1856-60 (1996).
Hara et al., Emulsion formulations as a vector for gene delivery in vitro and in vivo, Advanced Drug Delivery Reviews, vol. 24:265-71 (1997).

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