Formulation of antiinflammatory drugs

Details Formulation of antiinflammatory drugs Formulation of antiinflammatory drugs

1985-08-15

1987-01-13

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514371, A61K 3154, A61K 31425

Patent

active

046364986

ABSTRACT:
An improved antiinflammatory composition and method of treating inflammation which employs a combination of an antiinflammatory agent (e.g. indomethacin or an oxicam) with a histamine-H.sub.2 antagonist selected from the group consisting of 2-guanidino-4-(4-imidazolyl)thiazole, 2-guanidino-4-(2-methyl-4-imidazolyl )thiazole, 2-(N-benzyl-N'-guanidino)-4-(2-methyl-4-imidazolyl)thiazole, 2-(N-pentyl-N'-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and 2-guanidino-4-[2-(hexylamino)-4-imidazolyl]thiazole.

REFERENCES:
patent: 4230717 (1980-10-01), Lovelace
patent: 4447443 (1984-05-01), Goldenberg
Okabe et al., Am. J. Dig. Dis 22, pp. 677-684 (1977).
Brown et al., Eur. J. Pharmacol. 51, pp. 275-283 (1978).
Hayden et al., J. Pharm. Pharmacol. 30, pp. 244-246 (1977).
Djahanguiri et al., Eur. J. Pharmacol. 51, pp. 77-79 (1978).
Takeda et al., Arzneim-Forsch 32, pp. 734-737 (1982).
Croker et al., Ann. Rheum. Dis. 39, pp. 275-278 (1980).

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