Formulation for lipophilic IL-2 proteins

Details Formulation for lipophilic IL-2 proteins Formulation for lipophilic IL-2 proteins

1985-09-13

1991-02-12

Draper, Garnette

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 424 854, 424 855, 424 856, 424 857, 424 8591, 514 2, 514 8, 514 21, 514885, 514970, 514 12, 530351, 435811, A61K 3702, A61K 4502

Patent

active

049922718

ABSTRACT:
An improved process for recovering and purifying lipophilic recombinant proteins such as human .beta.-interferon and interleukin-2 from their hosts yields a protein preparation which may be formulated into a stable pharmaceutical composition having a therapeutically effective amount of the biologically active recombinant lipophilic protein dissolved in a non-toxic, inert, therapeutically compatible aqueous-based carrier medium at a pH of 6.8 to 7.8 which medium also contains a stabilizer for the protein, such as human serum albumin, normal serum albumin and human plasma protein fraction.

REFERENCES:
patent: 4289689 (1981-09-01), Friesen et al.
patent: 4315852 (1982-02-01), Leibowitz et al.
patent: 4343735 (1982-08-01), Menge et al.
patent: 4343736 (1982-08-01), Uemura et al.
patent: 4364863 (1982-12-01), Leibowitz et al.
patent: 4390623 (1983-06-01), Fabricius et al.
patent: 4401756 (1983-08-01), Gillis
patent: 4448879 (1984-05-01), Fabricius et al.
patent: 4450103 (1984-05-01), Konrad et al.
patent: 4460574 (1984-07-01), Yabrov
patent: 4462940 (1984-07-01), Hanisch et al.
patent: 4464355 (1984-08-01), Fabricius et al.
patent: 4490289 (1984-12-01), Stern
patent: 4508833 (1985-04-01), Sonneborn et al.
patent: 4530787 (1985-07-01), Shaked et al.
patent: 4569790 (1986-02-01), Koths et al.
patent: 4572798 (1986-02-01), Koths et al.
patent: 4604284 (1986-08-01), Kung et al.
patent: 4604377 (1986-08-01), Fernandes et al.
patent: 4645830 (1987-02-01), Yasushi et al.
patent: 4659570 (1987-04-01), Terano
patent: 4738927 (1988-04-01), Taniguchi et al.
patent: 4748234 (1988-05-01), Dorin et al.
patent: 4778879 (1988-10-01), Mertelsmann et al.
patent: 4789658 (1988-12-01), Yoshimoto et al.
patent: 4812557 (1989-03-01), Yasushi et al.
Mieu et al., J. Immunol., 128(3), 1982, pp. 1122-1127.
Mieu et al., Lymphokine, vol. 6, 1982, pp. 137-163.
Acuto et al., J. Immunological Methods, 53, 1982, pp. 15-26.
Caplan et al., 1981, J. Immunol., 26:1351-1354.
Welte et al., 1982, J. Exp. Med., 156:454.
Henriksen, O. et al., 1982, Cellular Immunol., 73:106-114.
Doyle, M. V. et al., 1985, J. Biol. Res. Mod., 4:96-109.
Robb, R. J., 1984, Immunol. Today, 5(7):203-209.
Robb, R. J. et al., 1981, Mol. Immunol., 18:1087-1094.
Robb, R. J. et al., 1983, Proc. Natl. Acad. Sci., 80:5990-5994.
Sofer, "Chromatographic Removal of Pyrogens", Bio/Technol., Dec. 1984:1035-1038.
Mochizuki et al., 1980, J. Immunol. Meth., 39:185-201.
Gillis, S. et al., 1980, J. Immunol., 124:1954-1962.
Berman et al., 1985, Trends in Biochemistry, 3(2):51-53.
Wang, Y.-C. J. et al., 1988, J. Parenteral Sci. and Technol., 42:S3-S26.
Stern et al., 1984, Immunol., 81:871-875.
Mertelsmann et al., 1984, J. Biol. Response Modifiers, 4:483-490.
Taniguchi et al., Nature, 302, 1983, pp. 305-310.
Rosenberg et al., Science, 223, 1984, pp. 1412-1415.
Devas et al., Nucleic Acid Res., 11(13), 1983, pp. 4306-4323.
Sakamoto et al., CA, vol. 104, 1986, #205522j.
Cancer Treatment Reports, vol. 62, No. 11, Nov. 1978, pp. 1900-1906.
Symbalista, Samuel, Chem. Abs., vol. 99, p. 353, (181455g), (1983), referring to EP 89,245, pub. 9/21/83.
Kwan, Henry, Chem. Abs., vol. 99, (76913g), (1983), referring to EP 82,481, publ. 6/29/83.

Affiliated with

Also associated with

Rating

Formulation for lipophilic IL-2 proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Formulation for lipophilic IL-2 proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Formulation for lipophilic IL-2 proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-19551