Formulation for I.V. administration of the boron delivery drug,

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Boron containing doai

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514 23, 568 6, 536124, A61K 3169

Patent

active

059359447

ABSTRACT:
A process and product formulated by complexing boronophenylalanine (BPA) and related compounds with a saccharide in an aqueous solution are disclosed. Formation of the complex is facilitated by raising the pH of the solution to a higher pH of about 10 or by lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process The pH manipulation causes a much higher solubility of BPA or related compounds and thus a higher boron concentration in the tumor, thereby improving the therapy.

REFERENCES:
patent: 4824659 (1989-04-01), Hawthorne
patent: 5021572 (1991-06-01), Gabel
patent: 5116980 (1992-05-01), Gabel
patent: 5144026 (1992-09-01), Gabel
patent: 5149801 (1992-09-01), Kahl et al.
patent: 5157149 (1992-10-01), Samsel
patent: 5492900 (1996-02-01), LaHann
LaHann, LR et al., Advances in Neutron Capture Therapy, Barth and Soloway, eds. 1 pp. 585-589, presented Sep. 14-17, 1992, Fifth International Symposium on Neutron Capture Therapy, Columbus, Ohio.
LaHann, Sills, et al., Advances in Neutron Capture Therapy, Barth and Soloway, eds; pp. 513-517, presented Sep. 14-17, 1992, Fifth International Symposium on Neutron Capture Therapy, Columbus, Ohio.
Barth, et al., Boron Neutron Capture Therapy for Cancer, Dec. 15, 1992, vol. 70, No. 12, pp. 2995-3007.
Soloway, et al., Evaluation of Boron Compounds for use in Neutron Capture Therapy of Brain Tumors. I. Animal Investigations, Mar. 10, 1961, vol. 134, pp. 117-122. J. Pharmacol. Exp. Therapeutics.
Mori, et al., Complex Formation of p-Boronophenylalanine With Some Monosaccharides, 1989, pp. 273-277 months not available.
Yoshino, et al., Improvement of solubility of p-boronphenylalanine by complex formation wtih monosaccharides, 1989, pp. 127-129 months not available.
Coderre, et al., Selective Targeting of Boronophenylalanine to Melanoma in BALB/c Mice for Neutron Capture Therapy, Sep. 10, 1987, pp. 6377-6383.
Coderre, et al., Selective Delivery of Boron by the Melanin Precursor Analog p-Boronophenylalanine to Tumors Others Than Melanoma, Oct. 2, 1989, pp. 138-141.
Mishima, et al., New Thermal Neutron Capture Therapy for Malignant Melanoma: Melanogenesis-Seeking .sup.10 B Molecule-Melanoma Cell Interaction From In Vitro to First Clinical Trial, Sep. 21, 1988, pp. 226-234.
Mallesch, et al., The Biodistribution of p-Boronophenylalanine-Fructose in Human Patients with Glioma and Metastatic Melanoma, 1993, pp. 735-738 months not available.
Buccholz, MD, et al., Concomitant Boron-Neutron Capture Therapy during Fast-Neutron Irradiation of a Rat Glioma.sup.1, 1994, pp. 863-867 months not available.
Barth, et al., A Nude Rat Model for Neutron Capture Therapy of Human Intracerebral Melanoma, Int. J. Radiation Oncology Biol. Phys., vol. 28, No. 5, pp. 1079-1088, 1994 months not available.
Mallesch, et al., The Pharmacokinetics of P-Boronophenylalanine.Fructorse in Human Patients with Glioma and Metastatic Melanoma, Int. J. Radiation Oncology Biol, Phys., vol. 28, No. 5, pp. 1183-1188, 1994 months not available.
Matalka, et al., Radiation Effects of Boron Neutron Capture Therapy on Brain, Skin, and Eye of Rats, Int. J. Radiation Oncology Biol. Phys., vol. 28, No. 5, pp. 1089-1097, 1994 months not available.
Coderre, et al., Neutron Capture Therapy of the 9L Rat Cliosarcoma Using the P-Boronophenylalanine-Fructose Complex, Int. J. Radiation Oncology Biol. Phys., vol. 30, No. 3, pp. 643-652, 1994 months not available.
Setiawan, et al., Effect of L-.sup.10 B-p-Boronophenylalanine-fructose and the Boron Neutron Capture Reaction on Mouse Brain Dopaminergic Neurons.sup.1, Feb. 15, 1995, pp. 874-877.
Fukuda, et al., Boron Neutron Capture Therapy of Malignant Melanoma Using .sup.10 B-Paraboronophenylalanine with Special Reverence to Evaluation of Radiation Dose and Damage to the Normal Skin, Radiation Research 138. 1994, pp. 435-442 months not available.
Matalka, Neutron Capture Therapy of a Rat Glioma Using Boronophenylalanine as a Capture Agent.sup.1,2, Radiation Research 137, 1994, pp. 44-51 months not available.

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