Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Boron containing doai
Patent
1996-02-20
1999-08-10
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Boron containing doai
514 23, 568 6, 536124, A61K 3169
Patent
active
059359447
ABSTRACT:
A process and product formulated by complexing boronophenylalanine (BPA) and related compounds with a saccharide in an aqueous solution are disclosed. Formation of the complex is facilitated by raising the pH of the solution to a higher pH of about 10 or by lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process The pH manipulation causes a much higher solubility of BPA or related compounds and thus a higher boron concentration in the tumor, thereby improving the therapy.
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Fonda Kathleen K.
Neutron Technology Corporation
Pedersen Barbara S.
Pedersen Ken J.
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