Formulation for controlled release of drugs by combining hydroph

Details Formulation for controlled release of drugs by combining hydroph Formulation for controlled release of drugs by combining hydroph

1995-06-02

1999-02-09

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 514953, A61K 4734, A61K 4736, A61K 910

Patent

active

058690794

ABSTRACT:
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide controlled, sustained drug release for an extended period of time.

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patent: 5385887 (1995-01-01), Yim et al.
R. Baker, "Controlled Release of Biologically Active Agents," A Wiley-Interscience Publication, p. 73 (1987).
Heller, Biodegradable Polymers in Controlled Drug Delivery (1987) CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 1, Issue 1:39-90.
Miller et al., Degradation Rates of Oral Resorbable Implants (Polylactates and Polyglycolates): Rate Modification with Changes in PLA/PGA Copolymer Ratios (1977) J. Biomed. Mater. Res., vol. 11:711-719.
Di Colo, Controlled Drug Release From Implantable Matrices Based On Hydrophobic Polymers (1992) Biomaterials, vol. 13, No. 12:850-856.
Jackanicz et al., Polyactic Acid As A Biogradable Carrier For Contraceptive Steroids (1973) Contraception, vol. 8, No. 3:227-235.

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