Formulation based on heparin, glycosaminoglycan or...

Details Formulation based on heparin, glycosaminoglycan or... Formulation based on heparin, glycosaminoglycan or...

2001-05-29

2008-07-01

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S772300

Reexamination Certificate

active

07393840

ABSTRACT:
The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.

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Serajuddin et al., Bioavailability Enhancement of Poorly Water-Soluble Drugs by Solid Dispersion in Surface Active and . . . , Journees Galeniques, 1997, pp. 43-50.
Leone-Bay et al., Synthesis and Evaluation of Compounds that Facilitate the Gastrointestinal Absorption of Heparin, J Med Chem, 1998, vol. 41(7), pp. 1163-1171.
Bachynsky et al., Factors Affecting the Efficiency of a Self-Emulsifying Oral Delivery System, Drug Development and Industrial Pharmacy, 1997, vol. 23(8), pp. 809-816.

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