Formulation

Details Formulation Formulation

2001-01-09

2004-08-10

Padmanabhan, Sreeni (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S178000

Reexamination Certificate

active

06774122

ABSTRACT:

The invention relates to a novel sustained release pharmaceutical formulation adapted for administration by injection containing the compound 7&agr;-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17&bgr;-diol, more particularly to a formulation adapted for administration by injection containing the compound 7&agr;-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17&bgr;-diol in solution in a ricinoleate vehicle which additionally comprises at least one alcohol and a non-aqueous ester solvent which is miscible in the ricinoleate vehicle.
Oestrogen deprivation is fundamental to the treatment of many benign and malignant diseases of the breast and reproductive tract. In premenopausal women, this is achieved by the ablation of ovarian function through surgical, radiotherapeutic, or medical means, and, in postmenopausal women, by the use of aromatase inhibitors.
An alternative approach to oestrogen withdrawal is to antagonise oestrogens with antioestrogens. These are drugs that bind to and compete for oestrogen receptors (ER) present in the nuclei of oestrogen-responsive tissue. Conventional nonsteroidal antioestrogens, such as tamoxifen, compete efficiently for ER binding but their effectiveness is often limited by the partial agonism they display, which results in an incomplete blockade of oestrogen-mediated activity (Furr and Jordan 1984, May and Westley 1987).
The potential for nonsteroidal antioestrogens to display agonistic properties prompted the search for novel compounds that would bind ER with high affinity without activating any of the normal transcriptional hormone responses and consequent manifestations of oestrogens. Such molecules would be “pure” antioestrogens, clearly distinguished from tamoxifen-like ligands and capable of eliciting complete ablation of the trophic effects of oestrogens. Such compounds are referred to as Estrogen Receptor-Downregulators (E.R.D.). The rationale for the design and testing of novel, pure antioestrogens has been described in: Bowler et al 1989, Wakeling 1990a, 1990b, 1990c. Wakeling and Bowler 1987, 1988.
Steroidal analogues of oestradiol, with an alkylsulphinyl side chain in the 7&agr; position, provided the first examples of compounds devoid of oestrogenic activity (Bowler et al 1989). One of these, 7&agr;-[9-(4,4,5,5,5-pentafluoropentyl sulphinyl)nonyl]oestra-1,3,5-(10)triene-3,17&bgr;-diol was selected for intensive study on the basis of its pure oestrogen antagonist activity and significantly increased antioestrogenic potency over other available antioestrogens. In vitro findings and early clinical experience with 7&agr;-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3-5(10)-triene-3,17&bgr;-diol have promoted interest in the development of the drug as a therapeutic agent for oestrogen-dependent indications such as breast cancer and certain benign gynaecological conditions.
7&agr;-[9-(4,4,5,5,5-Pentafluoropentylsulphinyl)nonyl]oestra-1,3-5(10)-triene-3,17&bgr;-diol, or ICI 182,780, has been allocated the international non-proprietary name fulvestrant, which is used hereinafter. When referring to fulvestrant we include pharmaceutically-acceptable salts thereof and any possible solvates of either thereof.
Fulvestrant binds to ER with an affinity similar to that of oestradiol and completely blocks the growth stimulatory action of oestradiol on human breast cancer cells in vitro; it is more potent and more effective than tamoxifen in this respect. Fulvestrant blocks completely the uterotrophic action of oestradiol in rats, mice and monkeys, and also blocks the uterotrophic activity of tamoxifen.
Because fulvestrant has none of the oestrogen-like stimulatory activity that is characteristic of clinically available antioestrogens such as tamoxifen or toremifene, it may offer improved therapeutic activity characterised by more rapid, complete, or longer-lasting tumour regression; a lower incidence or rate of development of resistance to treatment; and a reduction of tumour invasiveness.
In intact adult rats, fulvestrant achieves maximum regression of the uterus at a dose which does not adversely affect bone density or lead to increased gonadotrophin secretion. If also true in humans, these findings could be of extreme importance clinically. Reduced bone density limits the duration of oestrogen-ablative treatment for endometriosis. Fulvestrant does not block hypothalamic ER. Oestrogen ablation also causes or exacerbates hot flushes and other menopausal symptoms; fulvestrant will not cause such effects because it does not cross the blood-brain barrier.
European Patent Application No. 0 138 504 discloses that certain steroid derivatives are effective antioestrogenic agents. The disclosure includes information relating to the preparation of the steroid derivatives. In particular there is the disclosure within Example 35 of the compound 7&agr;-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17&bgr;-diol, which compound is specifically named in claim
4
. It is also disclosed that the compounds of that invention may be provided for use in the form of a pharmaceutical composition comprising a steroid derivative of the invention together with a pharmaceutically-acceptable diluent or carrier. It is stated therein that the composition can be in a form suitable for oral or parenteral administration.
Fulvestrant shows, along with other steroidal based compounds, certain physical properties which make formulation of these compounds difficult. Fulvestrant is a particularly lipophilic molecule, even when compared with other steroidal compounds, and its aqueous solubility is extremely low at around 10 ngml
−1
(this is an estimate from a water/solvent mixture solute since measurements this low could not be achieved in a water only solute).
Currently there are a number of sustained release injectable steroidal formulations which have been commercialised. Commonly these formulations use oil as a solvent and wherein additional excipients may be present. Below in Table 1 are described a few commercialised sustained release injectable formulations.
In the formulations within Table 1 a number of different oils are used to solubilise the compound and additional excipients such as benzyl benzoate, benzyl alcohol and ethanol have been used. Volumes of oil needed to solubilise the steroid active ingredient are low. Extended release is achievable for periods from 1 to 8 weeks.
TABLE 1
OIL BASED LONG-ACTING INTRAMUSCULAR INJECTIONS
PRODUCT NAME
STEROID
DOSE
TYPE
COMP′.
SUSTANON 100
Testosterone proprionate
30
mg
Androgen
Organon
Testosterone
60
mg
phenylproprionate
Testosterone isocaproate
60
mg
Testosterone decanoate
100
mg
PROLUTON
Hydroxy progesterone
250
mgml
−1
Progestogen
Schering
DEPOT
hexanoate
HC
TOCOGESTAN
Hydroxy progesterone
200
mg
Progestogen
Theramax
enantate
Progesterone
50
mg
&agr;-Tocopherol
250
mg
TROPHOBOLENE
Estrapronicate
1.3
mg
Mixed
Theramax
Nandrolone undecanoate
50
mg
Hydroxyprogesterone
80
mg
heptanoate
NORISTERAT
Norethisterone
200
mg
Contraceptive
Schering
oenanthoate
HC
BENZO-
Estradiol
5
mg
Estradiol
Roussel
GYNOESTRYL
hexahydrobenzoate
PROGESTERONE-
Hydroxy progesterone
250
mgml
−1
Progestogen
Pharlon
RETARD
caproate
GRAVIBINAN
Estradiol 17-&bgr;-valerate
5
mgml
−1
Mixed
Schering
Hydroxyprogesterone
250
mgml
−1
HC
caproate
PARABOLAN
Trenbolone
76
mg
Androgen
Negma
DELESTROGEN
Estradiol
20
mgml
−1
Estradiol
BMS
valerate
40
mgml
−1
DELALUTIN
17-Hydroxy
250
mgml
−1
Progestrogen
DMS
progesterone
PRODUCT NAME
SOURCE
OIL
BzBz
BzOH
EtOH
DOSE
DOSING
SUSTANON 100
ABPI Data
Arachis
0.1 ml
1 ml
3 weeks
Sheet
Comp. 1999
PROLUTON
ABPI Data
Castor
up to
1 or
1 week
DEPOT
Sheet
46%
2 ml
Comp. 1999
TOCOGESTAN
Dict. Vidal
Ethyl
*40%
2 ml
<1 week
1999
oleate
TROPHOBOLENE
Dict. Vidal
Olive
45%
1 ml
15 to 30
1997
days
NORISTERAT
ABPI Data
Castor
YES
1 ml
8 weeks
Sheet
Comp. 1999
BENZO-
Dict. Vidal
Arachis
1 ml
1 week
GYNOESTRYL
1998
PROGESTERONE
Dict. Vida

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