Formulated medicines for enhancing the efficacy of beta-lactam a

Details Formulated medicines for enhancing the efficacy of beta-lactam a Formulated medicines for enhancing the efficacy of beta-lactam a

1991-10-04

1993-03-30

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514192, 514200, 530832, 424439, 426532, 426657, A61K 3702, A61K 3143, A61K 31545, C07K 1300

Patent

active

051984199

ABSTRACT:
Lactoferrin can be used to increase the efficacy of beta-lactam antibiotics. There is a potentiating effect when lactoferrin is administered either simultaneous with or shortly before or after the administration of beta-lactam antibiotics. The dosage of lactoferrin administered is usually 0.5-100 mg/kg and preferably 1-10 mg/kg.

REFERENCES:
patent: 4153686 (1979-05-01), Nagel
patent: 4668771 (1987-05-01), Kawakami et al.
patent: 4726948 (1988-02-01), Prieels et al.
patent: 4977136 (1990-12-01), Nichols et al.
patent: 5019411 (1991-05-01), Johnson et al.
The Merck Manual, Berkow, Editor, pp. 98, 2305-2311, 1982.
Arnold et al., Infection and Immunity 28:893-898, Jun. 1980.
Mochizuki et al., Antimicrobial Agents and Chemotherapy 32: 1648-1654, Nov. 1988.

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