Forms of class II MHC transactivator (CIITA)

Details Forms of class II MHC transactivator (CIITA) Forms of class II MHC transactivator (CIITA)

1997-12-10

1999-11-30

Ketter, James

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1400

Patent

active

059945052

ABSTRACT:
Novel deletion mutants of the class II transactivator protein (CIITA) are disclosed. Isolated DNA encoding such mutants are also disclosed, as are recombinant DNA vectors containing said DNA, and antibodies that specifically bind the mutant CIITA proteins. Additionally, methods of treating disorders characterized by abnormal expression of major histocompatibility complex (MHC) antigens by administering novel mutants of the present invention are also disclosed.

REFERENCES:
patent: 5672473 (1997-09-01), Glimcher et al.
Brown et al.; Characterization Of The Expressed CIITA Allele In The Class II MHC Transcriptional Mutant RJ2.2.5., Immunogenetics, 43:88-91 (1995).
Lemon et al.; The RAG cell line defines a new complementation group of MHC class II deficiency, Immunogenetics, 43:352-359 (1996).
International Search Report mailed Apr. 13, 1998.
Riley, R.L. et al. Immunity. vol. 2, pp. 533-543, 1995.
Steimle, V. et al. Cell. vol. 75, pp. 135-146, Oct. 8, 1993.
Mach, B. et al. Annual Review of Immunology, vol. 14, pp. 301-331. Paul, Fathman and Metzger, eds. Annual Reviews, Inc. Palo Alto, 1996.

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