Forms of cabergoline

Details Forms of cabergoline Forms of cabergoline

2006-04-11

2006-04-11

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S288000, C546S067000

Reexamination Certificate

active

07026483

ABSTRACT:
The invention provides methods for preparing amorphous physical form of cabergoline, and solvate form A of cabergoline useful in the preparation of the first mentioned physical form. A method for treating a prolactin disorder with medicaments prepared from amorphous physical form of cabergoline and solvate form A of cabergoline is also disclosed.

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Ashford, S., et al., “A Practical Synthesis of Cabergoline,”J. Org. Chem.,67: 7147-50, 2002.
Brambilla, E., et al., “Synthesis and Nidation Inhibitory Activity of a New Class of Ergoline Derivatives,”Eur. J. Med. Chem.,24: 421-26, 1989.
Candiani, I., et al., “The Ligand Effect in Copper(I)-Catalyzed Chemoselective Amide Carbamoylation in Cabergoline Synthesis,”Synlett,605-06, 1995.
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