Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2008-03-11
2008-03-11
Puttlitz, Karl (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S220000, C564S221000
Reexamination Certificate
active
07342132
ABSTRACT:
A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
REFERENCES:
patent: 5434304 (1995-07-01), Trofast et al.
patent: 6268533 (2001-07-01), Gao et al.
patent: 6472563 (2002-10-01), Tanoury et al.
patent: 6475467 (2002-11-01), Keller et al.
patent: 6720453 (2004-04-01), Tanoury et al.
patent: 390762 (1992-10-01), None
patent: 2005492 (1989-01-01), None
patent: 2031407 (1992-01-01), None
patent: WO92/05147 (1992-04-01), None
patent: WO00/21487 (2000-04-01), None
Hett et al., “Large-Scale Synthesis of Enatio- and Diastereomerically Pure (R,R)-Formoterol” Organic Proc. Res. & Deve. 2, 96-99 (1998).
Hett et al., “Conformational Toolbox of Oxazaborolidine Catalysts in the Enantioselective . . . ” Tetr. Lett. 39, 1705-1708 (1998).
Hett et al., “Enantio- and Diastereoselective Synthesis of all Four Stereoisomers of Formoteol” Tetr Lett. 38, 1125-1128 (1997).
Murase et al. “New Beta-adrenoreceptor Stimulants Studies on 3-Acylamino-4-Hyroxy . . . ” Chem. Pharm. Bull. 25(6), 1368—1377 (1977).
Murase et al., “Absolute Configurations of four Isomers of 3-Formamido-4-Hydroxy . . . ” Chem. Pharm. Bull. 26(4), 1123-1129 (1978).
Trofast et al., “Steric Aspects of Agonism and Antagonism at Beta-Adrenoceptors: Synthesis . . . ” Chirality 3, 443-450 (1991).
Kurihara et al., “(-)-Formoterol, a Selective Beta 2-Adrenoreceptor Agonist” Acta Cryst. C53, 1887-1889 (1997).
Kessler Donald W.
Senanayake Chris H.
Tanoury Gerald J.
Heslin Rothenberg Farley & & Mesiti P.C.
Puttlitz Karl
Sepracor Inc.
LandOfFree
Formoterol tartrate process and polymorph does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Formoterol tartrate process and polymorph, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Formoterol tartrate process and polymorph will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2803784