Formimidoyl A and B useful as semi-synthetic aminoglycosidic ant

Details Formimidoyl A and B useful as semi-synthetic aminoglycosidic ant Formimidoyl A and B useful as semi-synthetic aminoglycosidic ant

1981-03-16

1983-05-10

Chan, Nicky

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 161, A61K 3171, C07H 1522

Patent

active

043829260

ABSTRACT:
New, useful derivatives of istamycins A and B are provided, which are formimidoylistamycins A and B of formula (I) having a toxicity significantly lower than those of istamycins A and B with an antibacterial activity higher than that of fortimicin A and of the same level as those of istamycins A and B. These compounds may be prepared by reacting 1,2',6'-tri-N-protected istamycins A and B of formula (V) with an iminoether.

REFERENCES:
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patent: 3976768 (1976-08-01), Nara et al.
patent: 4048015 (1977-09-01), Nara et al.
patent: 4091032 (1978-05-01), Tadanier et al.
patent: 4097428 (1978-06-01), Nara et al.
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patent: 4173564 (1979-11-01), Tadanier et al.
patent: 4174312 (1979-11-01), Tadanier et al.
patent: 4296106 (1981-10-01), Umezawa et al.
Yoshida et al., J. Antibiotics, 32, 964 (1979).
Yamamoto et al., ibid, 30, 1064 (1977).
Inouye et al., ibid, 32, 1354 (1979).
Nara et al., ibid, 30, 533 (1977).

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