Formation of triple helix complexes for the detection of double

Details Formation of triple helix complexes for the detection of double Formation of triple helix complexes for the detection of double

1994-02-10

1997-09-09

Arthur, Lisa B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 243, 536 253, C12Q 168, C07H 2100, C07H 2104

Patent

active

056655410

ABSTRACT:
A specific segment of double stranded DNA may be detected or recognized by formation of a triple helix structure using an Oligomer comprising an 8-modified purine base such as 8-oxo-adenine or 8-oxo-guanine to form a detectable triple helix complex. Function or expression of double stranded DNA segments may be prevented by triple helix formation. Novel Oligomers comprising an 8-modified purine base are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.

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