Formation of strong superporous hydrogels

Details Formation of strong superporous hydrogels Formation of strong superporous hydrogels

2006-06-06

2006-06-06

Zemel, Irina S. (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Cellular products or processes of preparing a cellular...

C521S102000, C521S109100, C521S125000, C521S130000, C521S140000, C521S142000, C521S149000, C521S182000, C525S054300

Reexamination Certificate

active

07056957

ABSTRACT:
The present invention features a method for the formation of superporous hydrogels using an ion-equilibration technique. Anionic polysaccharides are included in the hydrogel reaction mixture and cations are introduced either during or after hydrogel formation. Properties of the resulting hydrogel can be subsequently adjusted by treating the cation-complexed gel with a different cation or cation mixture under equilibrating conditions. It has been found that by properly adjusting the cations and the sequence in which they are used in the equilibration process, superporous hydrogels can be formed that are highly absorbent while maintaining favorable structural properties, including strength, ruggedness, and resiliency. It has also been found that applying appropriate dehydration conditions to them after their formation can further stabilize the superporous hydrogels formed by the method of the invention.

REFERENCES:
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Chen et al., “Synthesis of superporous hydrogels: hydrogels with fast swelling and superabsorbent properties,”J. Biomed. Mater. Res., 44(1):53-62.
Ishaug, et al., “Osteoblast function on synthetic biodegradable polymers,”J. Biomed. Mater. Res., 28(12):1445-1453 (1994).
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Mooney, et al., “Biodegradable sponges for hepatocyte transplantation,”J. Biomed. Mater. Res., 29(8):959-965 (1995).

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