Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-10-21
2008-12-30
Ketter, James S (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S320100, C424S450000, C536S023100
Reexamination Certificate
active
07470539
ABSTRACT:
Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic acid. Stabilized polycation
ucleic acid complexes can be modified to reduce the positive charge of the polycation and add targeting ligands without destabilizing the complex. The resultant particles retain their small size and are more effective in delivery of nucleic acid to cells in vivo.
REFERENCES:
patent: 7094605 (2006-08-01), Wakefield et al.
patent: 2001/0044412 (2001-11-01), Wolff et al.
patent: 2003/0220289 (2003-11-01), Monahan et al.
patent: 2003/0224055 (2003-12-01), Lowlo et al.
Budker Vladimir G.
Hagstrom James E.
Klein Jason
Rozema David B.
Trubetskoy Vladimir
Ekena Kirk
Johnson Mark K.
Ketter James S
Roche Madison Inc.
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