Formation of oligonucleotide triplexes with selectively modified

Details Formation of oligonucleotide triplexes with selectively modified Formation of oligonucleotide triplexes with selectively modified

1993-08-03

1995-04-18

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2532, 536 253, C12Q 168, C07H 2104

Patent

active

054078016

ABSTRACT:
An oligonucleotide or analog thereof including a single cytidine residue at a selected position and having one or more cytidine residues which are 5-methyl substituted. The cytidine nucleus can be selectively transaminated to include an aminoalkyl or carboxyalkyl group as a linker for other functional groups which can be used to form DNA duplexes and triplexes.

REFERENCES:
patent: 5082935 (1992-01-01), Cruickshank
Viscidi, R. P. et al. Novel chemical method for the preparation of nucleic acids in nonisotopic hybridization (J. Clin. Microbiol. (Feb. 1986) 23:311-317).
Ito, T., et al. Sequence-specific DNA purification by triplex affinity capture. (Proc. Natl. Acad. Sci. USA (Jan. 1992) 89:495-498.
Maher III, L. J., et al., Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation. Science (Aug. 18, 1989) 245:725-730.

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