Formation of hydroxy aryl carboxylic acids and esters

Details Formation of hydroxy aryl carboxylic acids and esters Formation of hydroxy aryl carboxylic acids and esters

1987-09-23

1989-05-09

Killos, Paul J.

Catalyst, solid sorbent, or support therefor: product or process

Solid sorbent

Having specifically intended extraneously added iron group...

560 56, 560 75, 549299, 549302, C07C 5110

Patent

active

048278459

ABSTRACT:
Hydroxy aryl carboxylic acids are formed by reacting a hydroxy aryl compound, such as phenol, with a ketone, such as acetone and carbon monoxide in the presence of a strong acid. The preferred embodiment is the one step formation of 2-methyl-2-(p-hydroxyphenyl) propionic acid from phenol, acetone and carbon monoxide in the presence of hydrofluoric acid. When this reaction is conducted in the presence of methanol the corresponding methyl ester is formed.

REFERENCES:
M. A. Heitkamp: "Fungal Metabolism of Tert-Butylphenyl Diphenyl Phosphate", Applied and Environmental Microbiology, Aug. 1985, pp. 265-273.
R. D. Burpitt et al; "The Reactions of Dimethylketene With Alpha-Dicarbonyl and Related Compounds" J. Org. Chem., vol. 36, No. 16, 1971.
A. Jonsson; "Studies on Antimetabolites": Acta Chemica Scandinavica, 8 (1954), 1211-1217, vol. 7.
B. Carnmalm et al; "Potential X-ray Contrast Agents"; Acta Pharm. Succica 11, 175 184 (1974).

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