Formation of human bone in vivo using ceramic powder and human m

Details Formation of human bone in vivo using ceramic powder and human m Formation of human bone in vivo using ceramic powder and human m

1997-02-12

1999-06-22

Lankford, Jr., Leon B.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424426, 424489, 424 937, 435325, 435366, 435372, 435395, A61F 200, A01N 6300, A61K 914, C12N 500

Patent

active

059141212

ABSTRACT:
An in vivo model for human bone metabolism. Human marrow stromal fibroblasts are isolated, expanded in culture, combined with ceramic powder (hydroxyapatite) delivery vehicles with or without fibrin glue and implanted into a mammal. This protocol results in the formation of self-maintained human bone which supports hematopoiesis. This model system can be used to screen compounds which inhibit or stimulate bone formation. The marrow stromal fibroblast delivery vehicles can be implanted into humans to augment bone implants or to repair bone defects.

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