Formation of and dehydration of hydroxylated diphenyl acetylenes

Details Formation of and dehydration of hydroxylated diphenyl acetylenes Formation of and dehydration of hydroxylated diphenyl acetylenes

1994-08-08

1995-11-28

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435132, 435155, 435170, 4352533, 435874, C12P 722, C12P 702, C12P 104

Patent

active

054707285

ABSTRACT:
Cis-dihydrodiol compounds of the formula ##STR1## where n is 0 or 1 (preferably 0) are produced by the microbial oxidation of a diphenylaceylene compound of the formula ##STR2## using a mutant of a Pseudomonas bacteria at 25.degree. to 35.degree. C. and pH 6-8. The cis-dihydrodiol compound is in turn treated with an aqueous solution of a base to produce a corresponding 3-hydroxydiphenylacetylene compound or with an aqueous solution of an acid to produce a corresponding 2-hydroxyacetylene compound. The mutant strain is preferably Pseudomonas ATCC 55272.

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