Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-11-02
1998-05-12
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 24, 435 6, 435188, 435325, 436 2, 436164, 436181, 530350, 536 231, C12Q 137, G01N 3100, G01N 2100, G01N 122
Patent
active
057503613
ABSTRACT:
Prion protein (PrP) peptides having at least one .alpha.-helical domain and forming a random coil conformation in aqueous solutions bind cellular PrP (PrP.sup.C) to form a complex having characteristics of the scrapie isoform (PrP.sup.Sc). Methods for screening compounds able to inhibit or decrease the binding of PrP peptides to PrP.sup.C are disclosed, as well as methods for assaying PrP.sup.Sc.
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Cohen Fred E.
Kaneko Kivotoshi
Prusiner Stanley B.
Bozicevic Karl
Hutzell Paula K.
Navarro Mark
The Regents of the University of California
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