Formation and resolution of ibuprofen lysinate

Details Formation and resolution of ibuprofen lysinate Formation and resolution of ibuprofen lysinate

1990-01-10

1991-02-19

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562402, 562496, C07B 5700

Patent

active

049946048

ABSTRACT:
A process is disclosed for the formation and resolution of (S)-ibuprofen-(S)-lysine. The process employs preferential crystallization to separate a pair of diasteromeric salts, (S)-ibuprofen-(S)-lysine and (R)-ibuprofen-(S)-lysine.

REFERENCES:
S. Yamada et al, J. Org. Chem. 38, 4408, pp. 1058-1062, (1973).
S. Yamada et al, J. Org. Chem. 40, 3360, pp. 1062-1065, (1975).

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