Formaldehyde derivatives of mitindomide

Details Formaldehyde derivatives of mitindomide Formaldehyde derivatives of mitindomide

1984-04-26

1987-06-02

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514316, 544 585, 544121, 544142, 544373, 546187, 546199, 548419, C07D20956, A61K 3140

Patent

active

046704612

ABSTRACT:
New substituted, formaldehyde derived mitindomide and methods of preparing the same are disclosed. The novel compounds are water soluble and have anti-neoplastic activity. The formaldehyde derived mitindomide is prepared by reacting mitindomide with formaldehyde and further acetylating the derived hydroxymethyl compound. The amido compounds can be derived by reacting mitindomide in mannich fashion, i.e-formaldehyde and secondary amines.

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