Form of a benzenesulfonamide derivative

Details Form of a benzenesulfonamide derivative Form of a benzenesulfonamide derivative

2011-01-11

2011-01-11

Andres, Janet L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S167000, C546S171000, C546S172000, C546S174000, C546S175000, C546S176000

Reexamination Certificate

active

07868174

ABSTRACT:
The present disclosure relates to an improved process for the preparation of enantiomerically enriched alcohols of Formula (I),from the corresponding ketone of Formula (II),by asymmetric transfer hydrogenation, using a hydrogen donor, catalyzed by a ruthenium or rhodium complex of an optically active N-sulfamoyl-1,2-diamine. R is as defined herein.

REFERENCES:
patent: 6184381 (2001-02-01), Ikariya et al.
patent: 0 480 717 (1992-04-01), None
Akio Fujii et al., “Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones Using a Formic Acid-Trithylamine Mixture”, J. Am. Chem. Soc. vol. 118, pp. 2521-2522, 1996.
Damjan Sterk et al., “New Chiral N-(N,N-dialkylamino)sulfamoy1-1,2-diamine ligands for highly enantioselective transfer hydrogenation of ketones”, Tetrahedron: Asymmetry, vol. 13, pp. 2605-2608, 2002.

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