Forensically acceptable determinations of gestational fetal expo

Details Forensically acceptable determinations of gestational fetal expo Forensically acceptable determinations of gestational fetal expo

1993-09-01

1994-07-05

Housel, James C.

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Diverse hetero atoms in same or different rings

436 57, 436173, 436174, 436501, 436546, 436901, G01N 3300

Patent

active

053267087

ABSTRACT:
Methods for collecting neonatal meconium samples, preparing meconium specimens for testing and for chemically analyzing neonatal meconium samples to determine their chemical composition are provided. A novel extraction method is employed in accordance with the invention to provide a non-aqueous, concentrated "cocktail" meconium extract containing substantially all of many possible target analytes in a single extraction step. Preliminary screening by fluorescence polarization immunoassay methods may be performed on the cocktail extract to qualitatively determine the presence of the target analytes in the meconium sample. If a positive preliminary result is obtained, new and improved quantitative GC/MS confirmatory procedures are provided by this invention to unequivocally identify and quantitate the amount of target analyte present in the sample in terms of nanograms of analyte per gram of meconium tested.

REFERENCES:
patent: 4868132 (1989-09-01), Brynes et al.
patent: 5015589 (1991-05-01), Ostrea, Jr.
patent: 5036014 (1991-07-01), Elsohly et al.
patent: 5096838 (1992-03-01), Grote et al.
patent: 5101015 (1992-03-01), Brynes et al.
patent: 5185267 (1993-02-01), Ostrea, Jr.
Ostrea, Jr., et al. "Adaptation of the Meconium Drug Test for Mass Screening", J. Pediatries, Jan. 1993, vol. 122, No. 1 pp. 152-154.
Hoyt et al. "Drug Testing in the Workplace-Are Methods Legally Defensible?", JAMA, Jul. 24/31, 1987 vol. 258 No. 4 pp. 504-509.
Martha Windholz, The Merck Index, 1983 p. 1092.
Sambrook, J. et al, "Molecular Cloning" 1989 p. E1.
Annino, Joseph et al., "Clinical Chemistry," 1977 pp. 80-84, 343.

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