Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-05-15
1999-11-30
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142358, 514252, 514326, 514392, A61K 31495, A61K 31435, A61K 31535, A61K 31415
Patent
active
059943475
ABSTRACT:
A process for the treatment of anxiety and tension, which comprises administering to a patient in need therefor an anxiolytically effective amount of a compound of the formula ##STR1## wherein X is hydrogen, a C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl residue, or halogen; R.sup.1 and R.sup.2 are independently of each other a C.sub.1-4 alkyl, cycloalkyl, C.sub.2-4 hydroxyalkyl, or heteroalkyl residue, or R.sup.1 and R.sup.2 together form a C.sub.2-6 alkylene residue in which one --CH.sub.2 -- group can be replaced by oxygen, nitrogen or sulfur; n is 0 or 1, and m is 0 or a cardinal number from 1-5, or a pharmaceutically acceptable salt of the compound.
REFERENCES:
patent: 4044021 (1977-08-01), Hanifin, Jr. et al.
patent: 5869481 (1999-02-01), Lankau et al.
E. Siegel et al.: The Antiepileptic Drug AWD 131-138 Stimulates Different Recombinant Isoforms of the Rat GABA, etc., Neurosci.Ltr. (1998), 245(2), pp. 85-88.
A. Rostock et al.: AWD 131-138 as Anxiolytic Anticonvulsant, Durgs Future (1998), 23(3), pp. 253-255.
Bartsch Reni
Dost Rita
Rostock Angelika
Rundfeldt Chris
Tober Christine
Arzneimittelwerk Dresden GmbH
MacMillan Keith D.
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