Food or edible material: processes – compositions – and products – Product with added vitamin or derivative thereof for...
Patent
1995-01-13
1996-06-18
Rollins, John W.
Food or edible material: processes, compositions, and products
Product with added vitamin or derivative thereof for...
426648, 514394, 514396, 514819, 514926, 514927, A23L 130, A61K 31415
Patent
active
055275486
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
The present invention relates to food products and to methods for preparing and treating them. Said food products contain a chemical substance which makes them easier for the body to assimilate.
More precisely, the invention provides a solution to the problem of the assimilation of foods of acid nature which are known to stimulation gastric and duodenum secretions.
The assimilation of those food products often cause in healthy individuals, disorders of a benign nature (indigestion, stomach burns . . . ). In can, in other individuals, create, with time, more serious disorders, which could lead to ulcers or peritonitis.
The conventional treatments for that kind of ailments, consist in removing from the diet any food which stimulates gastric and duodenum secretions and/or in administering: soda; and/or belladona.
These latter medicines have disturbing secondary effects, just like the histamine and parathyroidal extract often used for reducing pains.
These conventional treatments are restraining and often involve expensive medicines, which are difficult to administer, and can even be dangerous on a long term basis.
SUMMARY OF THE INVENTION
It is therefore the object of the present invention to substitute to all or part only of said medicines, a product which is inexpensive, innocuous and of easy administration.
The present invention proposes to this effect to use benzimidazole and/or at least one of its derivatives, directly mixed with the food products.
Said benzimidazole has the following formula: ##STR2##
Its derivatives, whether by addition or substitution, advantageously have the following formula: ##STR3## in which X and Y are, independently, an alkyl group, notably methyl, a phenyl group, a halogen . . .
DETAILED DESCRIPTION OF THE INVENTION
Benzimidazole is wellknown as a chemical compound, its first synthesis going back to over a hundred years (synthesis by reaction of o-phenylenediamine with formic acid: Wundt, Ber. 11, 826 (1878)).
This compound is very stable, particularly under heat, and it can withstand the action of concentrated acids, such as sulfuric and hydrochloric acids, and of alkalis.
Moreover, this compound has a wellknown biological activity, due to its chemical relation with histamine, and to its presence in the molecule of vitamin B12 (where it forms a bridge between the cobalt and one of the lateral chains, bonding of said chain being achieved with an amino-alcohol residue).
Benzimidazole and its derivatives are also already known to have pharmacological properties, which are not incompatible with their use within the scope of the present invention.
For example, the action of some of its derivatives on vasomotricity has been described, as well as the action of others against malaria.
It has also been shown that some of its derivatives exhibited remarkable fungicidal properties, of spectrum higher than that of griseofulvine, which are due to the blocking of the protein synthesis but which can be inhibited by the antagonist action of adenine, guanine, nucleic acids and vitamin B12 . . .
A study of the various pharmacological properties of the benzimidazole and of its derivatives has revealed the innocuousness of those substances. In particular, the LD.sub.50 of benzimidazole has been determined by the "Up and Down" method in mice. Said LD.sub.50 varies after 30 days, from 0.520 to 0.610 mg/g.
In the course of his works, the Applicant has determined the selective affinity and persistant concentration of benzimidazole and its derivatives, at the level of the gastro-duodenum mucosae, as well as the advantage that there is in ingesting said product or products at the same time as food products liable to cause stimulation and hypersecretion of said mucosae.
The selective affinity of benzimidazole towards the gastric mucose in mice and dogs as well as in humans, was established by autoradiographic and gammagraphic techniques, using the benzimidazole labeled with carbon 14 or iodine 131 and injected by intraperitoneol or intraveinous route.
It was found in b
REFERENCES:
patent: 4056108 (1977-11-01), Schumacher et al.
Food Science & Technology Abstracts, 1985. AC-No. 85-06-C0023. pp. 760-763.
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