Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-10-11
2005-10-11
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100, C536S023500
Reexamination Certificate
active
06953662
ABSTRACT:
The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
REFERENCES:
patent: 5942420 (1999-08-01), Holtzman
patent: WO-99/55865 (1999-04-01), None
patent: WO-99/25371 (1999-05-01), None
patent: WO-99/31237 (1999-06-01), None
U.S. Appl. No. 09/912,292, Rosen et al.
Genbank Accession No. N52331, Hillier et al., (Jan. 30, 1997), Genome Res., 6(9):807-828 (1996).
Genbank Accession No. AA552990, National Cancer Insitute, Cancer Genome Anatomy Project (Aug. 11, 1997).
Genbank Accession No. N28854, Hillier et al., The WashU-Merck EST Project (Jan. 4, 1996).
Genbank Accession No. R74502, Hillier et al., The WashU-Merck EST Project (Jun. 05, 1995).
Genbank Accession No. N75101, Hillier et al., (Jan. 30, 1997), Genome Res., 6(9):807-828 (1996).
Genbank Accession No. AC004156, Lamerdin et al., Sequence analysis of a 3.5 Mb contig in human 19p13.3 containing a serine protease gene cluster (Feb. 19, 1998).
Genbank Accession No. AA375541, Adams et al., (Apr. 21, 1997), Nature 377(6547 Suppl):3-174 (1995).
Genbank Accession No. AA363365, Adams et al., (Apr. 21, 1997), Nature Genet., 4:373-380 (1993).
Genbank Accession No. AC004156 Lamberdin et al., “Homo sapienschromosome 19, cosmid R33586.” (Feb. 19, 1998).
Genbank Accession No. AA227791, Hillier et al., Wash U.—Merck EST Project (Aug. 06, 1997).
Genbank Accession No. N32892, Hillier et al., Wash. U.—Merck EST Project (Jan. 10, 1996).
Genbank Accession No. AA470722, National Cancer Institute, Cancer Genome Anatomy Project (Aug. 14, 1997).
Genbank Accession No. AA492556, National Cancer Institute, Cancer Genome Anatomy Project (Aug. 19, 1997).
Genbank Accession No. N42037, Hillier et al., Wash. U.-Merck EST Project (Jan. 24, 1996).
Genbank Accession No. R72628, Hillier et al., Wash. U.-Merck EST Project (Jun. 02 ,1995).
Genbank Accession No. H42225, Hillier et al., Wash. U.-Merck EST Project (Jul. 31, 1995).
Genbank Accession No. H24937, Hillier et al., Wash. U.-Merck EST Project (Jul. 7, 1995).
Genbank Accession No. R79389, Hillier et al., Wash. U.-Merck EST Project (Jun. 9, 1995).
Genbank Accession No. H43043, Hillier et al., Wash. U.-Merck EST Project (Jul. 31, 1995).
Genbank Accession No. AA227956, Hillier et al., Wash. U.-Merck EST Project (Aug. 6, 1997).
Genbank Accession No. H14559, Hillier et al., Wash. U-Merck EST Project (Jun. 27, 1995).
Genbank Accession No. AA470654, National Cancer Institute, Cancer Genome Anatomy Project (Aug. 14, 1997).
Genbank Accession No. H42566, Hillier et al., Wash. U.-Merck EST Project (Jul. 31, 1995).
Genbank Accession No. R79390, Hillier et al., Wash. U.-Merck EST Project (Jun. 9, 1995).
Genbank Accession No. R72699, Hillier et al., Wash. U.-Merck EST Project (Jun. 2, 1995).
Genbank Accession No. AA258582, Hillier et al., Wash. U.-Merck EST Project (Aug. 6, 1997).
Genbank Accession No. AA365825 (Apr. 21, 1997), Adams et al., Nature, 377(6547 Suppl.):3-174 (1995).
Genbank Accession No. AA020306, Marra et al., Wash. U-HHMI mouse EST Project (Jan. 21, 1997).
Genbank Accession No. H51168, Hillier et al., Wash. U.-Merck EST Project (Sep. 18, 1995).
Genbank Accession No. R46195, Hillier et al., Wash. U.-Merck EST Project (May 10, 1995).
Genbank Accession No. AA015105, Marra et al., Wash. U-HHMI mouse EST Project (Jan. 21, 1997).
Genbank Accession No. W18317, Marra et al., Wash. U-HHMI mouse EST Project (Sep. 10, 1996).
Genbank Accession No. D31566 (Feb. 8, 1995), Sudo et al., Genomics, 24:276-279 (1995).
Genbank Accession No. W14649, Marra et al., Wash U-HHMI mouse EST Project (Sep. 10, 1996).
Genbank Accession No. AA568792, National Cancer Institute Cancer Genome Anatomy Project (Aug. 22, 1997).
Hayette et al., Oncogene, 16:2949-2954 (1998).
Shimasaki et al., PNAS, 85:4218-4222 (1988).
Genbank Accession No. AA421552, Hillier et al. “Homo sapienscDNA clone”(May 19, 1997).
European Search Report, Application No. EP 98 94 1072.5, dated Jul. 25, 2000.
International Search Report, Application No. PCT/US00/19198, dated Nov. 14, 2000.
Mikayama et al., Proc. Natl. Acad. Sci. USA, 90:10056-10060 (1993).
Voet et al., Biochemistry, John Wiley & Sons, Inc., pp.: 126-128 and 228-234 (1990).
Hemmati-Brivanlou, et al., Cell, 77:283-295 (1994).
Genbank Accession No. AA470722, National Cancer Institute, “Homo sapienscDNA clone” (Jun. 21, 1997).
Genbank Accession No. AA227791, Hillier et al., “Homo sapienscDNA clone” (Feb. 27, 1997).
Duan D. Roxanne
Ruben Steven M.
Human Genome Sciences Inc.
Human Genome Sciences Inc.
Mertz Prema
LandOfFree
Follistatin-3 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Follistatin-3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Follistatin-3 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3436382