Follistatin-3

Details Follistatin-3 Follistatin-3

2005-07-26

2005-07-26

Mertz, Prema (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S387900, C530S388100, C530S387300, C530S388150, C530S388230, C530S389200, C435S325000, C435S326000, C435S328000, C435S331000, C435S335000

Reexamination Certificate

active

06921644

ABSTRACT:
The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.

REFERENCES:
patent: 5942420 (1999-08-01), Holtzman
patent: WO 99/25371 (1999-05-01), None
patent: WO 99/31237 (1999-06-01), None
patent: WO 99/55865 (1999-11-01), None
U.S. Appl. No. 09/912,292, Rosen et al., Not Yet Published.
GenBank Accession No. AA227791 Hillier et al. Wash. U.-Merck EST Proj. (Aug. 6, 1997).
GenBank Accession No. N32892 Hillier et al., Wash. U-Merck EST Proj. (Jan. 10, 1996).
GenBank Accession No. AA470722 Nat. Cancer Inst. Cancer Genome Proj.(Aug. 14, 1997).
GenBank Accession No. AA492556 Nat. Cancer Inst. Cancer Genome Proj.(Aug. 19, 1997).
GenBank Accession No. N42037 Hillier et al., Wash. U-Merck EST Proj. (Jan. 24, 1996).
GenBank Accession No. R72628 Hillier et al., Wash. U-Merck EST Proj. (Jun. 2, 1995).
GenBank Accession No. H42225 Hillier et al., Wash. U-Merck EST Proj. (Jul. 31, 1995).
GenBank Accession No. H24937 Hillier et al., Wash. U-Merck EST Proj. (Jul. 7, 1995).
GenBank Accession No. R79389 Hillier et al., Wash. U-Merck EST Proj. (Jun. 9, 1995).
GenBank Accession No. H43043 Hillier et al., Wash. U-Merck EST Proj. (Jul. 31, 1995).
GenBank Accession No. AA227956 Hillier et al., Wash. U-Merck EST Proj. (Aug. 6, 1997).
GenBank Accession No. H14559 Hillier et al., Wash. U-Merck EST Proj. (Jun. 27, 1995).
GenBank Accession No. AA470654 Nat. Cancer Inst. Cancer Genome Proj. (Aug. 14, 1997).
GenBank Accession No. H42566 Hillier et al., Wash. U-Merck EST Proj. (Jul. 31, 1995).
GenBank Accession No. R79390 Hillier et al., Wash. U-Merck EST Proj. (Jun. 9, 1995).
GenBank Accession No. R72699 Hillier et al., Wash. U-Merck EST Proj. (Jun. 2, 1995).
GenBank Accession No. AA258582 Hillier et al., Wash. U-Merck EST Proj. (Aug. 6, 1997).
GenBank Accession No. AA365825 (Apr. 21, 1997) Adams et al., Nature 377 (6547 Sup.) 3-174 (1995).
GenBank Accession No. AA020306 Mara et al., Wash. U-HHMI mouse EST Proj. (Jan. 21, 1997).
GenBank Accession No. H51168 Hillier et al., Wash. U-Merck EST Proj. (Sep. 18, 1995).
GenBank Accession No. R46195 Hillier et al., Wash. U-Merck EST Proj. (May 10, 1995).
GenBank Accession No. AA015105 Marra et al., Wash. U-HHMI mouse EST Proj. (Jan. 21, 1997).
GenBank Accession No. W18317 Marra et al., Wash. U-HHMI mouse EST Proj. (Sep. 10, 1996).
GenBank Accession No. D31566 (Feb. 8, 1995) Sudo et al., Genomics 24:276-279 (1995).
GenBank Accession No. W14649 Marra et al., Wash. U-HHMI mouse EST Proj. (Sep. 10, 1996).
GenBank Accession No. AA568792 (Aug. 22, 1997) Nat. Cancer Inst., Cancer Genome Anatomy Project.
Hayette et al. “FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders” Oncogene 16:2949-2954 (1998).
Shimasaki et al., “Primary structure of the human follistatin precursor and its genomic organization” PNAS 85:4218-4222 (1988).
Online Database, Accession No. AA421522, Hillier et al., “Homo sapiens cDNA clone” (May 19, 1997).
European Search Report, Application No. EP 98 94 1072.5, dated Jul. 25, 2000.
European Search Report, Application No. PCT/US00/19198, dated Nov. 14, 2000.
Mikayama et al., PNAS 90:10056-10060 (1993).
Voet et al., John Wiley and Sons, Inc. pp. 126-128 and 228-234 (1990).
Hemmati-Briuanlou et al., Cell 77:283-295 (1994).
Genbank Accession No. N52331, Hillier et al., (Jan. 30, 1997), Genome Res., 6(9):807-828 (Jan. 30, 1997)**.
Genbank Accession No. AA552990, National Cancer Insitute, Cancer Genome Anatomy Project (Aug. 11, 1997)**.
Genbank Accession No. N28854, Hillier et al., The WashU-Merck EST Project (Jan. 4, 1996)**.
Genbank Accession No. R74502, Hillier et al., The WashU-Merck EST Project (Jun. 5, 1995)**.
Genbank Accession No. N75101. Hillier et al., (Jan. 30, 1997), Genome Res., 6(9):807-828 (Jan. 30, 1997)**.
Genbank Accession No. AC004156, Lamerdin et al., Sequence analysis of a 3.5 Mb contig in human 19p13,3 containing a sanne protease gene cluster (Feb. 19, 1998)**.
Genbank Accession No. AA975541, Adams et al., (Apr. 21, 1997). Nature 377(6547 Suppl):3-174 (1995)**.
Genbank Accession No. AA369965, Adams et al., (Apr. 21, 1997), Nature Genet., 4:373-380 (1993)**.
Genbank Accession No. AC004156 Lamerdin et al., “Homo sapiens chromosome 19, cosmid R33586”(Feb. 19, 1998)**.

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