Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-03-09
1988-03-29
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514800, 514843, 530300, 530350, 530853, A61K 3700, C07K 1500
Patent
active
047343982
ABSTRACT:
A protein moiety having a molecular weight of from 12,000 to 15,000 inhibits aromatase levels, stimulates 3.beta.-ol dehydrogenase levels and modulates the formation of mature ova substantially independently of steroidal sex hormones. The moiety may be isolated from follicular effluent or produced by granulosa cell cultures.
REFERENCES:
F. De Jong et al, Nature, vol. 263, 71-73, 1976.
diZerega, Gere S., et al., "Identification of Protein's Secreted by the Preovulatory Ovary which Suppresses the Follicle Response to Gonadotropins", Journal of Clinical Endocrinology and Metabolism, 54(6) (1982), pp. 1091-1096.
diZerega, Gere S., et al., "Identification of Proteins in Pooled Human Follicular Fluid which Suppress Follicular Response to Gonadotropins", Journal of Clinical Endocrinology and Metabolism, 56(1) (1983), pp. 35-41.
diZerega, Gere S., et al., "Human Granulosa Cell Secretion of Protein(s) which Suppress Follicular Response to Gonadotropins", Journal of Clinical Endocrinology and Metabolism, 56(1) (1983), pp. 147-155.
Brown J. R.
Rollins John W.
University of Southern California
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