Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-02-28
2006-02-28
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S059000, C514S058000, C514S056000, C536S055100, C536S051000, C536S046000, C536S021000, C436S505000
Reexamination Certificate
active
07005426
ABSTRACT:
The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and uses of said composition in therapy of tumors. The folic acid-polysaccharide complexs of the present invention have general formula of: (X)n—Y, wherein X is identical or different, and is selected from folic acid, derivatives of folic acid and other substances that can enter into cell via the pathway of folic acid receptor; Y is polysaccharide; n≧1.
REFERENCES:
patent: 4046722 (1977-09-01), Rowland
patent: 4857505 (1989-08-01), Arendt
patent: 5045535 (1991-09-01), Mang
patent: 5455236 (1995-10-01), Muller et al.
patent: 5547668 (1996-08-01), Kranz et al.
patent: 5554386 (1996-09-01), Groman et al.
patent: 383 170 (1990-08-01), None
patent: 1201014 (1970-08-01), None
patent: 59-152327 (1984-08-01), None
patent: 61-207237 (1985-03-01), None
patent: WO 90/12096 (1990-10-01), None
patent: WO 92/11037 (1992-07-01), None
Onishi et al. (Chemical and Pharmaceutical Bulletin, (Jun. 1986) 34(6), 2561-7).
Dang et al. (Cancer Research (Apr. 1, 1994) 54 (7) 1729-35).
Dang et al. (Cancer Research (Apr. 1, 1994) 54 (7) 1729-35) (abstract sent).
Chinese Patent No. 1,081,688 (Abstract only).
“Measurement of endosome pH following folate receptor-mediated endocytosis” Robert J. Lee, Susan Wang, Phillip S. Low,Biochimica et Biophysica Acta 1312(1996) 237-242.
“Iron Oxide Nanoparticles as Magnetic Resonance Contrast Agent for Tumor Imaging via Folate Receptor-targeted Delivery”, Hoon Choi, PhD et al.,Academic Radiology, vol. 11, No. 9, (2004).
XP-002309369, Biosis database, “Tetratogenicity Studies with Methotrexate Aminopterin and Acetyl Salicylic-Acid in Domestic Cats”, Tetratology 14(1):21-27 (1976) (Abstract).
Liu Min
Lu Weiyue
Pan Jun
Darby & Darby
Henry Michael C.
Shanghai Pharmco Research, Inc.
Wilson James O.
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