Folic acid derivatives and process for preparation

Details Folic acid derivatives and process for preparation Folic acid derivatives and process for preparation

1979-10-31

1982-02-09

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 424 12, 544257, G01N 3356, G01N 3360, G01T 100

Patent

active

043149880

ABSTRACT:
Folic acid derivatives, such as radiolabeled pteroyltyrosine, are conveniently synthesized from either pteroic acid or by the direct condensation of 6-formylpterin with p-aminobenzoyltyrosine methyl ester. The radioiodinated derivatives are particularly useful in competitive protein binding and radioimmuno-assays of folate compounds.

REFERENCES:
patent: 3972991 (1976-08-01), Caston et al.
patent: 3989812 (1976-11-01), Barrett et al.
patent: 4028465 (1977-06-01), Lewin et al.
patent: 4091087 (1978-05-01), Barrett et al.
patent: 4115065 (1978-09-01), Bayly et al.
patent: 4135880 (1979-01-01), Mangiardi et al.
patent: 4146602 (1979-03-01), Gutcho et al.

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