Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1979-04-30
1981-11-03
Coughlan, Jr., Paul M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
23230B, 424 1, 424 15, 544258, 544260, C07D47504
Patent
active
042987350
ABSTRACT:
Folic acid derivatives, such as radiolabeled pteroyltyrosine, are conveniently synthesized from either pteroic acid or by the direct condensation of 6-formylpterin with p-aminobenzoyltyrosine methyl ester. The radioiodinated derivatives are particularly useful in competitive protein binding and radioimmuno-assays of folate compounds.
REFERENCES:
patent: 3972991 (1976-08-01), Caston et al.
patent: 3989812 (1976-11-01), Barrett et al.
patent: 4091087 (1978-05-01), Barrett et al.
patent: 4146602 (1979-03-01), Gutcho et al.
Farina Peter R.
Grattan James A.
Coughlan, Jr. Paul M.
Evans J. Hart
Union Carbide Corporation
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