folC from Streptococcus pneumoniae

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide

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4241841, 4241851, 4241901, 4242001, 435243, 530350, 530806, 530808, 530820, 530825, A61K 3900, A61K 3938, A61K 3902, C12N 100, C07K 100

Patent

active

061654728

ABSTRACT:
The invention provides folC polypeptides and DNA (RNA) encoding folC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing folC polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5565204 (1996-10-01), Kuo et al.
Lazar Mol Cell Biol 8(3):1247-1252, 1988.
Burgess J Cell Biol 111:2129-2138, 1990.
Jazin Reg Pept 47:247-258, 1993.
Rudinger Peptide Hormones Edited by Parsons NIMR, London, 1976.
Herzog DNA Cell Biol 12(6):465-471, 1993.
Eddy ATCC No.: Organism (6301-6312) (Public Health Rep. 59:449-468 ATCC Catalogue 17 Edition, p. 208, 1989.
Lopez, et. al..,GenBank Submission, Accession No. U16156, M17362, M58706, "Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme. "

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