Folate targeted enhanced tumor and folate receptor positive...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

08043603

ABSTRACT:
A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.

REFERENCES:
patent: 2816110 (1957-12-01), Sletzinger et al.
patent: 4577636 (1986-03-01), Spears
patent: 4641650 (1987-02-01), Mok
patent: 4713249 (1987-12-01), Schroder
patent: 4718417 (1988-01-01), Kittrell et al.
patent: 4785806 (1988-11-01), Deckelbaum
patent: 4817601 (1989-04-01), Roth et al.
patent: 4850351 (1989-07-01), Herman et al.
patent: 4917084 (1990-04-01), Sinofsky
patent: 4950266 (1990-08-01), Sinofsky
patent: 5094848 (1992-03-01), Brixner
patent: 5108921 (1992-04-01), Low et al.
patent: 5140104 (1992-08-01), Coughlin et al.
patent: 5192525 (1993-03-01), Yang et al.
patent: 5217456 (1993-06-01), Narciso
patent: 5266333 (1993-11-01), Cady et al.
patent: 5275594 (1994-01-01), Baker et al.
patent: 5336506 (1994-08-01), Josephson et al.
patent: 5373093 (1994-12-01), Vallarino et al.
patent: 5399338 (1995-03-01), Born et al.
patent: 5416016 (1995-05-01), Low et al.
patent: 5417982 (1995-05-01), Modi
patent: 5547668 (1996-08-01), Kranz et al.
patent: 5552545 (1996-09-01), Pearce et al.
patent: 5562100 (1996-10-01), Kittrell et al.
patent: 5576305 (1996-11-01), Ratcliffe
patent: 5688488 (1997-11-01), Low et al.
patent: 5753631 (1998-05-01), Paulson et al.
patent: 5759546 (1998-06-01), Weinberg et al.
patent: 5820847 (1998-10-01), Low et al.
patent: 6093382 (2000-07-01), Wedeking
patent: 6167297 (2000-12-01), Benaron
patent: 6204371 (2001-03-01), Levinson
patent: 6217847 (2001-04-01), Contag et al.
patent: 6246901 (2001-06-01), Benaron
patent: 6270766 (2001-08-01), Feldman et al.
patent: 6335434 (2002-01-01), Guzaev et al.
patent: 6387350 (2002-05-01), Goldenburg
patent: 6507747 (2003-01-01), Gowda et al.
patent: 6780984 (2004-08-01), Wang et al.
patent: 6782289 (2004-08-01), Strauss
patent: 7033594 (2006-04-01), Low et al.
patent: 7128893 (2006-10-01), Leamon et al.
patent: 7223380 (2007-05-01), Yang et al.
patent: 7601332 (2009-10-01), Vlahov
patent: 2001/0031252 (2001-10-01), Low et al.
patent: 2002/0127181 (2002-09-01), Edwards et al.
patent: 2002/0192157 (2002-12-01), Low et al.
patent: 2003/0162234 (2003-08-01), Jallad et al.
patent: 2003/0198643 (2003-10-01), Lu
patent: 2003/0219375 (2003-11-01), Piwnica-Worms
patent: 2004/0033195 (2004-02-01), Leamon et al.
patent: 2004/0057900 (2004-03-01), Edwards et al.
patent: 2004/0184990 (2004-09-01), Larsen et al.
patent: 2005/0002942 (2005-01-01), Viahov et al.
patent: 2005/0026866 (2005-02-01), Pawelek
patent: 2005/0244336 (2005-11-01), Low
patent: 2006/0002891 (2006-01-01), Pouletty
patent: 2006/0067946 (2006-03-01), Low et al.
patent: 2006/0204565 (2006-09-01), Low et al.
patent: 2007/0009434 (2007-01-01), Low et al.
patent: 2007/0031334 (2007-02-01), Leamon et al.
patent: 2007/0231266 (2007-10-01), Low et al.
patent: 2007/0276231 (2007-11-01), Low et al.
patent: 2008/0119475 (2008-05-01), Low et al.
patent: 2008/0138396 (2008-06-01), Low et al.
patent: 2008/0254499 (2008-10-01), Low et al.
patent: 2009/0012009 (2009-01-01), Low et al.
patent: 21 23338 (1996-11-01), None
patent: 90/12096 (1990-10-01), None
patent: 91/19501 (1991-12-01), None
patent: 91/19502 (1991-12-01), None
patent: 96/36367 (1996-11-01), None
patent: 97/37690 (1997-10-01), None
patent: 01/19320 (2001-03-01), None
patent: 01/39806 (2001-06-01), None
patent: 01/74382 (2001-10-01), None
patent: 02/087424 (2002-11-01), None
patent: 2004/110250 (2004-12-01), None
patent: 2005/087275 (2005-09-01), None
patent: 2006/012527 (2006-02-01), None
patent: 2006/071754 (2006-07-01), None
patent: 2006/101845 (2006-09-01), None
patent: 2007/006041 (2007-01-01), None
patent: 2008/098112 (2008-08-01), None
patent: 2009/002993 (2008-12-01), None
patent: WO 2008/148001 (2008-12-01), None
Leamon et al (DDT vol. 6 No. 1 Jan. 2001:44-51).
Mahmood et al. Radiology, 1999. 213:866-870.
Greenman, Y., et al., “Heterogeneous Expression of Two Somatostatin Receptor Subtypes in Pituitary Tumors,” Journal of Clinical Endocrinology and Metabolism, vol. 78, No. 2, pp. 398-403 (1994).
NCBI, MeSH definition for “Indocarbocyanine Green,” 2 pages, Sep. 2009.
Weissleder, R., et al., “In Vivo Imaging of Tumors with Protease-Activated Near-Infrared Fluorescent Probes,” Nature Biotechnology, vol. 17, pp. 375-378 (1999).
U.S. Appl. No. 61/235,220, filed Aug. 19, 2009, Low et al.
U.S. Appl. No. 61/157,847, filed Mar. 5, 2009, Low et al.
Antohe et al., “Increased uptake of folate conjugates by activated macrophages in experimental hyperlipemia”, Cell Tissue Research, vol. 320, No. 2, pp. 277-285, May 2005.
Aviram et al., “Intralipid infusion abolishes ability of human serum to cholesterol-load cultured macrophages”, Arteriosclerosis, vol. 9, pp. 67-75, 1989.
Barrera et al., “Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis”, Arthritis and Reheumatism, vol. 43, pp. 1951-1959, Sep. 2000.
Beaumont et al., “Selective Fluorodenitration of Chloronitroaromatics”, J. Fluorine Chem., vol. 63, pp. 25-30, 1993.
Bettio et al., “Synthesis and Preclinical Evaluation of a Folic Acid Derivative Labeled with 18F for PET Imaging of Folate Receptor-Positive Tumors”, The Journal of Nuclear Medicine, vol. 47, No. 7, pp. 1153-1160, 2006.
Bock et al., “Sulfonamide Structure-Activity Relationships in a Cell-Free System. 2. Proof for the Formation of a Sulfonamide-Containing Folate Analog”, Journal of Medicinal Chemistry, vol. 17, No. 1, pp. 23-28, 1974.
Boechat et al., “Fluorodenitrations Using Tetramethylammonium Fluoride”, J. Soc. Chem, Commun., pp. 921-992, 1993.
Bonasera et al., “The Synthesis of [26, 27-11C]Dihydroxyvitamin D3, a Tracer for Positron Emission Tomography (PET), Bioorganic & Medicinal Chemistry”, Elsevier Science Ltd., vol. 9, pp. 3123-3128, 2001.
Budinger et al., “New Approaches to Targeting Arthritis with Radiopharmaceuticals”, The Journal of Rheumatology, 22(1) Supp: 62-67, 1995.
Burke et al., “Book Review. The Macrophage”, British Journal of Cancer, vol. 89, p. 421, 2003.
Chen et al., “MicroPET Imaging of Brain Tumor Angiogenesis with 18F-Labeled PEGylated RGD Peptide”, European Journal of Nuclear Medicine and Molecular Imaging, vol. 31, No. 8, pp. 1081-1089, Aug. 2004.
Cochlovius, “Therapeutic Antibodies”, Modern Drug Discovery, vol. 6, pp. 33-38, Oct. 2003.
Cox et al., “Anhydrous, Tetrabutylammonium Fluoride: A Mild but Highly Efficient Source of Nucleophilic Fluoride Ion”, J. Org. Chem., No. 49, pp. 3216-3219, Feb. 8, 1984.
Degrado et al., “Synthesis and Evaluation of (18)F-Labeled Choline Analogs as Oncologic PET Tracers”, J. Nuclear Medicine, vol. 42, No. 12, pp. 1805-1814, 2001.
Feldman et al., “Anti-TNFa Therapy Is Useful in Rheumatoid Arthritis and Crohn's Disease: Analysis of the Mechanism of Action Predicts Utility in Other Diseases”, Transplant. Proc. , 30, pp. 4126-4127, 1998.
Garg et al., “Fluorine-18 Labeling of Monoclonal Antibodies and Fragments with Preservation of Immunoreactivity”, Bioconjugate Chem., vol. 2, No. 1, pp. 44-49, 1991.
Giroldo et al., “An Unusually Fast Nucleophilic Aromatic Displacement Reaction: The Gas-Phase Reaction of Fluoride Ions with Nitrobenzene”, Angew. Chem. Int. Ed., No. 43, pp. 3588-3590, 2004.
Godwin et al., “The synthesis of biologically active pteroyloligo-g-L-glutamates (folic acid conjugates): Evaluation of (3H) pteroylheptaglutamate for metabolic studies”, Journal of Biological Chemistry. vol. 247, pp. 2266-2271, 1972.
Gotoh, “Causes and treatment of rheumatoid arthritis; recent trend I. Progress in pathogenesis of rheumatoid arthritis; role of macrophages and dendritic cells”, Pharma Nedica, Japan Medical Review Co., Ltd., Tokyo, 17(10): 35-39, 1999.
Hamacher et

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Folate targeted enhanced tumor and folate receptor positive... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Folate targeted enhanced tumor and folate receptor positive..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Folate targeted enhanced tumor and folate receptor positive... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4286296

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.