Folate-receptor-targeting iron oxide nanoparticles coated...

Details Folate-receptor-targeting iron oxide nanoparticles coated... Folate-receptor-targeting iron oxide nanoparticles coated...

2007-06-29

2009-10-06

Gulakowski, Randy (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From silicon reactant having at least one...

C528S028000, C424S009300, C424S009323

Reexamination Certificate

active

07598335

ABSTRACT:
The present invention provides the synthetic method and superparamagnetic iron oxide nanoparticles capable of targeting to the folic acid receptors existing on the cell membranes and with high relaxivity. The iron oxide nanoparticles of the present invention can further be used as the contrast agents for magnetic resonance imaging (MRI).

REFERENCES:
patent: 2004/0249082 (2004-12-01), Zhang et al.
patent: 2006/0216239 (2006-09-01), Zhang et al.
patent: 2007/0269380 (2007-11-01), Zhang et al.
Sun et al. J. Am. Chem. Soc., 2002, 124, 8204-8205.
Nathan Kohler et al., A Bifunctional Poly(ethylene glycol) Silane Immolbilized on Metallic Oxide-Based Nanoparticles for Conjugation with Cell Targeting Agents, J.Am. Chem. Soc. 2004, vol. 126, pp. 7206-7211.

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