Foam laminate transdermal patch

Details Foam laminate transdermal patch Foam laminate transdermal patch

1993-05-18

1996-04-02

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424434, 424447, 424448, 521159, 521172, 521174, A61F 1300, A61F 1302

Patent

active

055038441

ABSTRACT:
Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.

REFERENCES:
patent: 4573996 (1986-03-01), Kwiatek et al.
patent: 4597961 (1986-07-01), Etscorn
patent: 4710191 (1987-12-01), Kwiatek et al.
patent: 4820525 (1989-04-01), Leonard et al.
patent: 4839174 (1989-06-01), Baker et al.
patent: 4911916 (1990-03-01), Cleary
patent: 5016652 (1991-05-01), Rose et al.

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