FO-6979 substances and process for producing the same

Details FO-6979 substances and process for producing the same FO-6979 substances and process for producing the same

2007-03-20

2007-03-20

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

C435S071100, C435S252100, C514S008100, C514S011400, C530S317000

Reexamination Certificate

active

10343990

ABSTRACT:
(Beauveria) sp. FO-6979 (FERM BP-6681), which belongs to the genusBeauveriaand is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby accumulate the FO-6979-M0, -M1, -M2, -M3 and -M4 substances in the liquid culture medium. Then the FO-6979-M0, -M1, -M2, -M3 and -M4 substances are collected from the culture medium. The substances thus obtained are less toxic, specifically inhibit acyl-Coenzyme A: cholesterol acyltransferase, and inhibit the formation of oil droplets in macrophages. Owing to these characteristics, the above substances are useful in preventing and treating human diseases caused by cholesterol accumulation.

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