Fluoroquinoline derivative

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546156, A61K 3147, C07D215233, C07D21518, C07D21556

Patent

active

057769486

ABSTRACT:
Antibacterial fluoroquinoline derivatives and salts thereof of the following formula are stable and have low toxicity and high photostability and low cytotoxicity under light irradiation: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl;

REFERENCES:
patent: 4880814 (1989-11-01), Chu
patent: 4929613 (1990-05-01), Culbertson
patent: 4945160 (1990-07-01), Kiely
patent: 5039682 (1991-08-01), McGuirk
patent: 5137892 (1992-08-01), Chu
patent: 5527910 (1996-06-01), Kim
patent: 5545642 (1996-08-01), Petersen
patent: 5597923 (1997-01-01), Nagano
Domagala, J of Medicinal Chemistry, vol. 29, No. 4, pp. 445-448, 1986.
Sanchez, J of Medicinal Chemistry, vol. 31, No. 5, pp. 983-991, 1988.
Chemical Abstracts, abstract No. 174003d, Preparation of 4-quinolinone-4-carbxylates as Medical Bacterides, vol. 111 No. 19, pp. 714-715, Nov. 6, 1989.
Chemical Abstracts, abstract No. 185293m, Antibacterial Quinoline Derivatives and Their Salts, vol. 114, No. 19, May 13, 1991.

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