Fluoropyrrolidines having dipeptidyl peptidase enzyme...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S252010, C514S256000, C514S275000, C544S330000, C544S336000

Reexamination Certificate

active

07655663

ABSTRACT:
The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.

REFERENCES:
patent: 2004/0024236 (2004-02-01), Vanduffel
patent: 2004/0242636 (2004-12-01), Haffner et al.
patent: 2005/0176771 (2005-08-01), Hayakawa
patent: PCT/JP03/09179 (2003-07-01), None
patent: PCT/JP03/09179 (2005-08-01), None
“Tautomer.” Retrieved online via the Internet [Dec. 9, 2008] URL:www.en.wikipedia.org/wiki/Tautomer.
“Isomer.” Retrieved online via the Internet [Dec. 9, 2008] URL: www.en.wikipedia.org/wiki/isomer.
Patani, George A. Bioisosterism: A rational approach in drug design. Chem. Rev. 96 (1996) 3147-3176.
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta et al., abstract, Vippagunta, Sudha R. “Crystalline Solids.” Advanced Drug Delivery Reviews 48(2001): 3-26.

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