Fluorophores for encapsulation into liposomes

Details Fluorophores for encapsulation into liposomes Fluorophores for encapsulation into liposomes

1987-06-29

1990-03-27

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424 71, 424 9, 549223, 549403, 558 8, 544300, C07D31182, G01N 3352

Patent

active

049122088

ABSTRACT:
The present invention provides novel fluorescein derivative compounds having fluorescence spectrum and quantum yield characteristics similar to those of fluorescein. The compounds are readily synthesized and purified and are readily soluble in water at self-quenching concentrations. Significantly, due to the presence of polar polyhydroxy group substituents and the absence of metal-chelating groups, these fluorescein derivatives are susceptible to minimal leakage across liposome membranes and have fluorescence characteristics minimally sensitive to the presence of metal ions. Compounds of the invention are thus exceptionally suitable for use in the development of highly storage stable liposome preparations to be employed in immunolytic assays involving human body fluid samples.

REFERENCES:
patent: 4130634 (1978-12-01), Molinaro et al.
patent: 4304720 (1981-12-01), Dean et al.
patent: 4318846 (1982-03-01), Khanna et al.
patent: 4342826 (1982-08-01), Cole
patent: 4350676 (1982-09-01), Laties et al.
patent: 4476229 (1984-10-01), Fino et al.
patent: 4510251 (1985-04-01), Kirkemo et al.
patent: 4614823 (1986-09-01), Kirkemo et al.
patent: 4668640 (1987-05-01), Wang et al.
Allen et al., Biochimica et Biophysica Acta., 597:418-426 (1980).
Barbet, Inserm, 107:27-36 (1982).
Ishimiro et al., Journal of Immunological Methods, 75:351-360 (1984).
Kataoka et al., Eur. J. Biochem., 24:123-127 (1971).
Kendall et al., Analytical Biochemistry, 134:26-33 (1983).
Kendall et al., The Journal of Biological Chemistry, 257:13892-13895 (1982).
Lelkes et al., Biochimica et Biophysica Acta., 716:410-419 (1982).
O'Connell et al., Clin. Chem., 31:1424-1426 (1985).
Struck et al., Biochemistry, 20:4093-4099 (1981).
Vanderwerf et al., Biochimica et Biophysica Acta., 596:302-314 (1980).
Weinstein et al., Science, 195:489-492 (1977).
Wilschut et al., Biochemistry, 19:6011-6021 (1980).
Yasuda et al., Journal of Immunological Methods, 44:153-158 (1981).
Haga et al., Analytical Biochemistry, 118:286-293 (1981).
Haga et al., Biochemical and Biophysical Research Communications, 95:187-192 (1980).
Gregoriadis et al., Biochem. J., 129:123-133 (1972).
Gregoriadis et al., Biochem., 24:485-491 (1972).
Hsia et al., Annals New York Academy of Sciences, 139-149 (1978).
Uemura et al., Biochemistry, 11:4085-4094 (1972).
Six et al., Biochemistry, 12:4003-4011 (1973).
Six et al., Biochemistry, 13:4050-4058 (1971).
Ryman et al., Essays in Biochemistry, 16:49-98 (1980).
Wei et al., Journal of Immunological Methods, 9:165-170 (1975).
Smolarsky et al., Journal of Immunological Methods, 15:255-265 (1977).
Gregoriadis et al., Nature, 244:170-172 (1973).
Sessa et al., J. of Biological Chemistry, 245:3295-3301 (1970).
Chan et al., J. of Immunological Methods, 21:185-195 (1978).

Affiliated with

Also associated with

Rating

Fluorophores for encapsulation into liposomes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorophores for encapsulation into liposomes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorophores for encapsulation into liposomes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1651928