Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-08-30
1998-03-03
Leary, Louise
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 23, 435 4, 435968, 530316, 530300, 530330, 562 89, C12Q 137, C12Q 100, G01N 3353, A61K 3800
Patent
active
057233071
ABSTRACT:
Disclosed are new fluorogenic substrates for assay of angiotensin converting enzyme, a process for preparing them and methods for using them to assay angiotensin converting enzyme and to screen antihypertensive agents which inhibit angiotensin converting enzyme.
REFERENCES:
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Carmel, Amos and Yaron, Arich "An Intramolecularly Quenched Fluorescent Tripeptide As A Fluorogenic Substrate of Angiotensin-I-Converting Enzyme and a Bacterial Dipeptidyl Carboxypeptidase." Eur. J. Biochem. 87, 265-273 (1978) Month not Available.
Fleminger, Gideon, et al. "Use of An Intramolecularly Quenched Fluorogenic Substrate For Study Of A Thiol-Dependent Acidic Dipeptidyl Carboxypeptidase In Cellular Extracts And In Living Cells." FEBS Letters 135, 131-134 (1981) Month not Available.
Sato, Eisuke et al. "Novel Fluorogenic Substrates Containing Bimane System For Microdetermination of Angiotensin I Converting Enzyme." Chem. Pharm. Bull. 37, 145-147 (1989) Month no Available.
Sato, Eisuke et al. "Bimane Fluorogenic Substrates For Microdetermination of Angiotensin Converting Enzyme Level In Serum." Chem. Pharm. Bull. 39, 2146-2148 (1991) Month not Available.
Matayoshi, Edmund D. et al. "Novel Fluorogenic Substrates for Assaying Retroviral Proteases by Resonance Energy Transfer." Science 247, 954-958 (1990) Month not Available.
Maggiora, Linda L. et al. "A General Method For The Preparation of Internally Quenched Fluorogenic Protease Substrates Using Solid-Phase Peptide Synthesis." J. Med. Chem. 35, 3727-3730 (1992) Month not Available .
Chen Hui-Ling
Tsai Hsin
Development Center for Biotechnology
Leary Louise
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