Fluorogenic substrate glycosides

Details Fluorogenic substrate glycosides Fluorogenic substrate glycosides

1973-08-27

1976-04-13

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

1951035R, 260211R, 260234R, 424180, C07H 1706

Patent

active

039503224

ABSTRACT:
There are provided novel fluorogenic substrates comprising a ketoside formed between an N-acyl neuraminic acid and a highly fluorescent material containing a phenolic grouping. The presence of neuraminidase is detected by contacting the aforementioned fluorogenic substrate with a sample suspected of containing neuraminidase. Neuraminidase, if present, cleaves the ketosidic linkage, releasing the fluorescent material which is then detected by known methods. There is also provided a novel and efficient method of preparing such fluorogenic substrates utilizing cadmium carbonate as a catalyst.

REFERENCES:
patent: 3152115 (1964-10-01), Morel et al.
patent: 3427300 (1969-02-01), Sarette et al.
patent: 3445455 (1969-05-01), Kiss et al.
patent: 3755118 (1973-08-01), Partridge et al.
patent: 3758455 (1973-09-01), Arita

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