Chemistry: analytical and immunological testing – Oxygen containing – Carbonyl – ether – aldehyde or ketone containing
Patent
1992-06-17
1994-05-10
Johnston, Jill A.
Chemistry: analytical and immunological testing
Oxygen containing
Carbonyl, ether, aldehyde or ketone containing
436 93, 436 94, 436127, 436129, 436161, 436162, 436172, 549438, 549439, 560 21, 560 22, 560 45, 560 48, 562435, 562437, 562452, 562458, G01N 2164, G01N 3364, C07C20500, C07C22900
Patent
active
053106822
ABSTRACT:
Compounds containing .alpha.-discarbonyl groups are rendered capable of fluorescent emission by conjugation with carboxylic acid-terminated ortho-diaminoaryl reagents. The carboxylic acid groups serve as ionizable moieties which facilitate the conjugation reaction, and are retained in the conjugation product to enable, or enhance the ability of, the conjugated compounds to be separated in chromatographic and electromigration separation processes, notably electrophoresis. Ortho-dinitro derivatives of the reagents are also disclosed, these derivatives offering the advantage of stability as well as the ability to be used directly in the reaction in the presence of a reducing agent.
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Novotny Milos V.
Shirota Osamu
Wiesler Donald
Indiana University Foundation
Johnston Jill A.
Soderquist Arlen
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