Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-01-30
1994-08-16
Rizzo,, Nicholas
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
435 18, C07D50134, A61K 31545
Patent
active
053388437
ABSTRACT:
Chromogenic and fluorogenic substrates for .beta.-lactamase, methods for synthesis thereof and methods for detecting .beta.-lactamase in a sample are provided. The substrates are substantially colorless or substantially nonfluorescent .beta.-lactam compounds which include an electronegative leaving group. The leaving group comprises a carbamate, carbonate, thiocarbamate or thiocarbonate linkage and a fluorescent moiety or a moiety capable of producing a visually detectable colored product. Upon cleavage of the lactam ring by .beta.-lactamase, the leaving group is liberated and fluorescence or a colored product is produced.
REFERENCES:
patent: 3355452 (1967-11-01), Urech et al.
patent: 3484437 (1969-12-01), Urech et al.
patent: 4740459 (1988-04-01), Chen et al.
patent: 4965193 (1990-10-01), Chen
patent: 4978613 (1990-12-01), Bieniarz et al.
patent: 5049665 (1991-09-01), Nakagawa et al.
patent: 5114933 (1992-05-01), Bertrandie et al.
patent: 5189157 (1993-02-01), Wei et al.
Hoke Randal A.
Millner, deceased O. Elmo
Mize Patrick D.
Quante J. Michael
Woodard Daniel L.
Becton Dickinson and Company
Fugit Donna R.
Rizzo Nicholas
LandOfFree
Fluorogenic and chromogenic .beta.-lactamase substrates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fluorogenic and chromogenic .beta.-lactamase substrates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorogenic and chromogenic .beta.-lactamase substrates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-953022