Fluorochromes for labelling biomolecules and polymer...

Details Fluorochromes for labelling biomolecules and polymer... Fluorochromes for labelling biomolecules and polymer...

2005-12-27

2005-12-27

Ceperley, Mary E. (Department: 1641)

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

C435S006120, C435S007210, C435S007500, C530S391500, C530S405000, C436S172000, C436S503000, C436S527000, C544S217000, C548S440000, C548S159000

Reexamination Certificate

active

06979575

ABSTRACT:
New reactive dyes are described which can be used to fluorescently label bioorganic molecules such as amino acids, proteins, antibodies, nucleotides and also polymer particles. The color of the new dyes and conjugates thereof can be varied over a wide range. In contrast to known symmetric cyanine dyes, the dyes of the invention contain only one reactive group. Hence the labelling takes place without the interfering cross-linking that occurs with bireactive dyes. Their fluorescence quantum yields are very high (especially in the conjugated form). Conjugates thereof with proteins, oligonucleotides or particles can be used in fluorescence-based analytical methods of determination e.g. in immunoassays, in hybridization assays, in cytometry or for pharmaceutical screening.

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