Fluoroalkoxy substituted benzimidazoles useful as gastric acid s

Details Fluoroalkoxy substituted benzimidazoles useful as gastric acid s Fluoroalkoxy substituted benzimidazoles useful as gastric acid s

1984-05-01

1985-11-26

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546271, C07D40312, A61K 3144

Patent

active

045555184

ABSTRACT:
Fluoroalkoxy compounds of the general formula I ##STR1## wherein R1 represents a 1-3C-alkyl radical which is completely or predominantly substituted by fluorine, or a chlorodifluoromethyl radical, R1' represents hydrogen, halogen, trifluoromethyl, a 1-3C-alkyl radical, or a 1-3C-alkoxy radical which is optionally completely or predominantly substituted by fluorine, R2 represents hydrogen or a 1-3C-alkyl radical, R3 represents hydrogen or a 1-3C-alkyl or 1-3C-alkoxy radical, R4 represents hydrogen or a 1-3C-alkyl radical and n represents the number 0 or 1, and their salts are new compounds with a marked protective effect on the stomach.

REFERENCES:
patent: 4045563 (1977-08-01), Berntsson et al.
patent: 4045564 (1977-08-01), Berntsson et al.
patent: 4337257 (1982-06-01), Janggren et al.
Yale, J. Med. and Pharm. Chemistry, vol. 1, No. 2, 1959, p. 131.
Pinder et al., J. of Pharm. Sci., vol. 56, No. 8, 1967, 970-971.

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