Fluoro-substituted biphenylyl compounds and processes

Details Fluoro-substituted biphenylyl compounds and processes Fluoro-substituted biphenylyl compounds and processes

1982-04-16

1983-12-27

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465G, 562492, C07C12166, C07C 5323

Patent

active

044229798

ABSTRACT:
2-(2-Fluoro-4-biphenylyl)propionic acid is prepared from 2-amino-4-methylbiphenyl via a series of novel intermediates. In particular 2-amino-4-methylbiphenyl is converted to 2-fluoro-4-methylbiphenyl, the methyl group is brominated to form 2-fluoro-4-monobromomethylbiphenyl which is transformed into 2-(2-fluoro-4-biphenylyl)acetonitrile. This acetonitrile is then converted to flurbiprofen via the corresponding propionitrile or it may be converted into flurbiprofen via the intermediate ethyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate.

REFERENCES:
patent: 3755427 (1973-08-01), Adams et al.
patent: 3959364 (1976-05-01), Armitage et al.

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