Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1998-04-09
2000-05-02
Keys, Rosalynd
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C07C 6112, C07C23301, C07C23358, C07C21134
Patent
active
060573643
ABSTRACT:
The invention relates to fluoro-substituted adamantane derivatives of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined herein. The invention also relates to methods of treating neurological disorders, such as memory loss and Parkinson's disease, and bacterial and viral infections, through administration of a therapeutically effective amount of a compound of formula I. The invention also relates to a method of increasing the metabolic stability of an adamantane-containing pharmaceutical compound by incorporating a fluoro substituent on at least one bridge-head carbon of the adamantyl group of said adamantane-containing pharmaceutical compound
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Jasys Vytautas John
Volkmann Robert A.
Ginsburg Paul H.
Keys Rosalynd
Koller Alan L.
Pfizer Inc
Richardson Peter C.
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